Current Concepts of Cerebrovascular Disease — Stroke Clinical Relevance of Models of Cerebral Ischemia
نویسندگان
چکیده
A MAJOR CONSIDERATION in the evaluation of experimental models of ischemic stroke in animals is the clinical relevance of the models. Difficulties arise in relating studies of models of focal cerebral ischemia to the clinical situations of strokes in humans because of many factors, including species differences, the effects of anesthesia, and the progressive nature of atherosclerosis. However, certain physiological and chemical studies cannot be done in humans. Thus, it is important to know in what ways experimental models of ischemia are similar to or different from strokes in humans.
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